'Structures of Closed and Open Conformations of Dimeric Human ATM' (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

'Structures of Closed and Open Conformations of Dimeric Human ATM' (1 of 2)

Caption

Dimeric huma ATM kinase in equilibrium between closed and open state. Open state may be representative of an active form of the ATM kinase, which activates DNA double strand break repair and consequently inhibits cells cycle progression. This material relates to a paper that appeared in the 10 May 2017, issue of Science Advances, published by AAAS. The paper, by D. Bareti? at Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, and colleagues was titled, "Structures of closed and open conformations of dimeric human ATM."

Credit

[Credit: The image was prepared by Roger L. Williams and Domagoj Baretic, MRC Laboratory of Molecular Biology, Cambridge, U.K.]

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.