Reverse Engineering the BH4 Pathway (IMAGE)

Boston Children's Hospital

Reverse Engineering the BH4 Pathway

Caption

'Reverse engineering' the BH4 pathway reveals sepiapterin reductase as a new target for analgesic treatments. This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab-designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the 'bridge' between the two species.

Credit

Image: Alban Latremoliere

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