Graphical Abstract (IMAGE)

AlphaMed Press

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The common pathological symptom of dys- and de-myelinating diseases is uncompact myelin ensheathments of the axons. Our findings suggest that FBLN5 binds to the Integrin receptors and promotes actin remodeling through RAC1 activation in the Schwann cells. Then, the Schwann cells are recovered by an activated actin remodeling mechanism and induce the compact myelination of the diseased axons.

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AlphaMed Press

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