Synaptic Disorder (IMAGE)

University of Würzburg

Synaptic Disorder

Caption

This is an electron microscope image of synaptic vesicles in the axon terminals of reference motor neurons (left) and Plekhg5-deficient motor neurons (right) at 100,000x magnification. Dysfunctional synaptic vesicles that are degraded in healthy individuals accumulate in Plekhg5-deficient motor neurons and lead to functional loss of synaptic transmission. Such dysfunctional, enlarged vesicles are marked with asterisks.

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(Picture: Peter Heimann)

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