Graphic Representation (IMAGE) Saarland University Caption Both unfolded proteins and aberrant membrane lipid compositions are sensed by Ire1 and can activate the so-called unfolded protein response. This pathway is crucial for the function and survival of secretory cells such as antibody-producing plasma cells. Credit Robert Ernst Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.