Degeneration of Dendritic-Specific Golgi Complex in the Brain Cells (IMAGE)

DGIST (Daegu Gyeongbuk Institute of Science and Technology)

Degeneration of Dendritic-Specific Golgi Complex in the Brain Cells

Caption

This figure shows degeneration of dendritic-specific Golgi complex in the brain cells by accumulation of polyglutamine toxic protein in the nucleus and its mechanism of early neuropathy. A comparison of brain cell in normal (left) and brain cell (right) in patients with degenerative brain disease. The study has demonstrated for the first time in the world that the polyglutamine toxin protein accumulated in the nucleus of the brain cell inhibits the transcription factors CBP and CrebA. As a result, the dendritic-specific Golgi cannot be properly formed and causes the morphological transformation of the brain cell.

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DGIST

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