Surface Functionalization of Peptoid-Coated DNA Origami (IMAGE)

DOE/Brookhaven National Laboratory

Surface Functionalization of Peptoid-Coated DNA Origami

Caption

A schematic showing how "alkyne" reactive groups incorporated into peptoid sequences coating the DNA origami can conjugate with fluorophore-labeled nanocargo (such as trastuzumab) that have been modified with "azide" chemical groups (red shape). Through alkyne-azide click-chemistry reactions, the surface of peptoid-coated DNA origami can be functionalized.

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Brookhaven National Laboratory

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