Sonic Hedgehog Drug Improves Down Syndrome Symptoms in Mice (1 of 1) (IMAGE)

American Association for the Advancement of Science (AAAS)

Sonic Hedgehog Drug Improves Down Syndrome Symptoms in Mice (1 of 1)

Caption

SAG treatment at birth normalizes cerebellar structure in adult Ts65Dn mice, which exhibit some of the major brain structural and behavioral phenotypes of Down syndrome. Representative sagittal images of TsSAG, TsVeh, and EuVeh cerebella in adult mice convey the difference in size and neuronal density.This image relates to a paper that appeared in the September 4, 2013, issue of Science Translational Medicine, published by AAAS. The paper, by I. Das at Johns Hopkins University School of Medicine in Baltimore, Md., and colleagues was titled, "Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model."

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Image courtesy of <i>Science Translational Medicine</i>/AAAS

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