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Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)

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The figure illustrates the role of the mitochondrial Ca2+/Na+ exchanger (NCLX) in the early adaptation to low oxygen concentrations (hypoxia) through the entry of sodium into the mitochondrial interior. This role is exemplified by hypoxic vasoconstriction of the pulmonary artery, which connects the heart to the lungs. A drop in oxygen concentration activates the transport of sodium to the mitochondrial interior, and this triggers signals leading to constriction of the artery. Elimination of NCLX blocks the arterial response to drops in oxygen concentration.

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CNIC

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