Amino Acid Transporters as Disease Modifiers and Drug Targets (IMAGE)

SLAS (Society for Laboratory Automation and Screening)

Amino Acid Transporters as Disease Modifiers and Drug Targets

Caption

The binding site of the EAAT1 inhibitor (UCPH101) is resolved by X-ray crystallography and is located at a distance from the substrate binding site. The substrate is shown in the center of the transporter, while the inhibitor is located between the translocation and scaffold domain of the transporter (lower right). The inhibitor glues the two domains together, thereby inhibiting transport.

Credit

Stefan Broer

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