New Clarity in the Imaging of Bone Tumors (2 of 2) (IMAGE)
Caption
Longitudinal monitoring by intravital multiphoton microscopy of an osteolytic lesion (an area of bone loss due to cancer) in bone treated with zoledronic acid. The same osteolytic lesion was captured 3, 6, and 9 days after administration of zoledronic acid. The resulting images were superimposed to generate a visual map of osteolytic progression (each day is represented with a different color: red, blue or green). The left part of the lesion is stable, while the right part shows advancing bone resorption. The signal detected corresponds to OsteoSense 750 (a fluorescent imaging agent). This material relates to a paper that appeared in the 1 August, issue of Science Translational Medicine, published by AAAS. The paper, by E. Dondossola at The University of Texas MD Anderson Cancer Center in Houston, TX; and colleagues was titled, "Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone."
Credit
Eleonora Dondossola and Peter Friedl, David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center
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