Could a Noncoding RNA Be a New Drug Target for Heart Disease? (IMAGE)

American Association for the Advancement of Science (AAAS)

Could a Noncoding RNA Be a New Drug Target for Heart Disease?

Caption

Abnormal enlargement of the heart muscle, known as cardiac hypertrophy, can lead to heart failure. A new study pinpoints a long noncoding RNA called <i>Chast</i>, which drove cardiac hypertrophy in mice, as a potential therapeutic target for the disease. This material relates to a paper that appeared in the Feb. 17, 2016, issue of <i>Science Translational Medicine</i>, published by AAAS. The paper, by J. Viereck at Hannover Medical School in Hannover, Germany, and colleagues was titled, "Long noncoding RNA <i>Chast</i> promotes cardiac remodeling."

Credit

C. Bickel / <i>Science Translational Medicine</i> (2016)

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