How Does The Body Respond To Diffuse Cutaneous Leishmaniasis? (IMAGE)
Caption
Aspects of B cell, T cell, and macrophage responses contribute to parasite survival in DCL patients. Increased B cell presence and altered antibody repertoires promote anti-inflammatory phenotypes in the lesion microenvironment. This nullifies parasite killing, and possibly promotes the diffuse nature of the disease. Increased anti-inflammatory factors also negate TH1 cell activation, cytotoxic T cell infiltration, activation, and T cell effector functions necessary for clearance of intracellular pathogens.
Credit
Christensen, et al. (CC BY 4.0, 2019)
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