Structure of Enzyme Seen as Target for ALS Drugs (1 of 2) (IMAGE)

University of Texas Health Science Center at San Antonio

Structure of Enzyme Seen as Target for ALS Drugs (1 of 2)

Caption

The Dbr1 enzyme (red, blue and orange surfaces) binds to part of an intron lariat (seen as yellow, white and green sticks). This is the first visualization of a Dbr1-intron lariat interaction. Partially inhibiting Dbr1 could represent a new way to treat most cases of amyotrophic lateral sclerosis (ALS).

Credit

P. John Hart, Ph.D., X-ray Crystallography Core Laboratory, The University of Texas Health Science Center at San Antonio

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