Endurance Exercise May Play Role in Regulating Telomere Transcription (IMAGE)

American Association for the Advancement of Science (AAAS)

Endurance Exercise May Play Role in Regulating Telomere Transcription

Caption

The age-dependent loss of telomere integrity limits the replicative capacities of our tissues. The study by Diman et al. shows that endurance exercise stimulates telomere transcription into long non-coding RNA molecules with important functions at telomeres. This process, dependent on the AMPK/PGC-1alpha/NRF1 metabolic pathway, is likely to contribute to telomere protection. This material relates to a paper that appeared in the Kuly 27, 2016, issue of Science Advances, published by AAAS. The paper, by A.M. Diman at Université catholique de Louvain in Brussels, Belgium, and colleagues was titled, "Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription."

Credit

Aurélie Diman and Anabelle Decottignies

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