Development of Autoimmune Inflammation Can Be Followed with Increasing Age in Individual Mice (IMAGE)

American Journal of Pathology

Development of Autoimmune Inflammation Can Be Followed with Increasing Age in Individual Mice

Caption

Upon inflammation, a transcription factor (NF-kB) activates the translation of a firefly protein (Luciferase) generating photons in cells of diseased tissues. The technique is highly sensitive and predicts development, severity and outcome of disease. Top: Skin disease with gradual involvement of ears and snout. Middle: Arthritis development, light signals appear several weeks before clinical signs. Bottom: Development of inflammatory signals from the intestines (inflammatory bowel disease, and perianal inflammation).

Credit

Zangani et al, Am J Pathol, 2009

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