Damaged Mitochondria Are Selectively Eliminated Via Autophagy Called Mitophagy (IMAGE)

Tokyo Metropolitan Institute of Medical Science

Damaged Mitochondria Are Selectively Eliminated Via Autophagy Called Mitophagy

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Damaged mitochondria are selectively eliminated via autophagy called mitophagy. In mammalian cells, ubiquitin chains on the damaged mitochondria play critical roles to induce mitophagy. Researchers at Tokyo Metropolitan Institute of Medical Science (TMIMS) discovered that the critical autophagy adaptor OPTN (optineurin) interacts with ATG9A, the leucine zipper domain (LZ) in OPTN is essential for their interactions, and the OPTN-ATG9A binding plays a critical role in ubiquitin-mediated mitophagy (Yamano et al., Journal of Cell Biology 2020).

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TMiMS

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