Macrophage Activation Syndrome in COVID-19 (IMAGE)

Hokkaido University

Macrophage Activation Syndrome in COVID-19

Caption

SARS-CoV-2 enters cells via the ACE2 receptor. It causes cell death in lung cells, and these dying cells release cytokines that activate macrophages. Separately, the virus that enters macrophages activates them. These activated macrophages recruit T cells, which in turn activate more macrophages. This becomes a positive feedback loop that leads to MAS and subsequently hyperinflammation. (Ryo Otsuka, Ken-ichiro Seino. Inflammation and Regeneration. August 6, 2020)

Credit

Ryo Otsuka, Ken-ichiro Seino. Inflammation and Regeneration. August 6, 2020.

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