Improved AAV Vector Capsid for Gene Therapy Engineered with a New Machine-Guided Approach (IMAGE)

The Yates Network

Improved AAV Vector Capsid for Gene Therapy Engineered with a New Machine-Guided Approach

Caption

Improved AAV vector capsid for gene therapy engineered with a new machine-guided approach shows, in red, improvements in efficiency of viral production based on the average effect of insertions at all possible amino acid positions, with white showing neutral and blue showing deleterious positions. (Left: capsid viewed from outside, Right: cut-out to reveal inner positions).

Credit

Eric Kelsic, Dyno Therapeutics

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