Genetic Mutation in Brittle Bone Disease Linked to Collagen Defects (IMAGE)

American Association for the Advancement of Science (AAAS)

Genetic Mutation in Brittle Bone Disease Linked to Collagen Defects

Caption

Skeletons from wild-type and Tric-b knockout mice show impaired bone mineralization in the latter. The preparations were stained with Alcian blue (cartilage) and Alizarin red (bone). Scale bars, 5 mm. This material relates to a paper that appeared in the May 18, 2016 issue of Science Translational Medicine, published by AAAS. The paper, by C. Zhao at Kyoto University in Kyoto, Japan, and colleagues was titled, "Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization."

Credit

Zhao <i>et al. / Science Signaling</i> (2016)

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