EEG Studies in Patients, Mice Reveal the Roots of Essential Tremor (2 of 3) (IMAGE)

American Association for the Advancement of Science (AAAS)

EEG Studies in Patients, Mice Reveal the Roots of Essential Tremor (2 of 3)

Caption

In patients with essential tremor, we found that neurons called Purkinje cells (PCs) in the cerebellum gradually loss a protein called GluRδ2. This protein loss leads to the overgrowth of cerebellar neuronal fibers, which generate too much synchronization and oscillations in the cerebellar neurons and thus cause tremor. PC: Purkinje cell; CF: climbing fiber of the cerebellum; EEG: electroencephalography. This material relates to a paper that appeared in the Jan. 15, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by M.-K. Pan at National Taiwan University Hospital in Taipei City, Taiwan; and colleagues was titled, "Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology."

Credit

Ming-Kai Pan, M.D., Ph.D. and Sheng-Han Kuo, M.D.

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