GDH Protein (IMAGE)

Université de Genève

GDH Protein

Caption

Hyperinsulinism is linked to the GDH protein. When open (at left), the protein can more easily attach itself to a molecule that is necessary for its activity than when it is closed (at right): this sends a signal instructing the pancreas to produce insulin. A mutation of the GDH protein disrupts this mechanism and keeps the protein open, which in turn leads to insulin overproduction.

Credit

Pierre Maechler / UNIGE

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