P53 and Somatic Cell Reprogramming (IMAGE) Salk Institute Caption Downregulating p53 activity increases the reprogramming efficiency of adult somatic cells requiring only two reprogramming factors instead of the usual four. Credit Courtesy of Dr. Juan-Carlos Belmonte, Salk Institute for Biological Studies Usage Restrictions News media reproduction to illustrate this story permitted with proper attribution as provided above. For one time use only. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.