Proposed Model of LL-37 Induced Mutagenesis and Mucoid Conversion (IMAGE)

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Proposed Model of LL-37 Induced Mutagenesis and Mucoid Conversion

Caption

This shows the proposed model of LL-37 induced mutagenesis and mucoid conversion. Step Ia, at low doses LL-37 (*) interacts with Pseudomonas aeruginosa and enters bacterial cells, binding to DNA (Step Ib). LL-37/DNA interactions promote mucA mutagenesis and conversion to the mucoid phenotype (Step II). Mucoid P. aeruginosa biofilms are now more resistant to killing by lethal levels of LL-37 and are selected for in the CF pulmonary environment (Step III).

Credit

Wozniak et. al

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