New Vulnerability in Breast Cancer Cells (IMAGE)

University of Helsinki

New Vulnerability in Breast Cancer Cells

Caption

New study reveals that FGFR4 phosphorylates the essential proteins (MST1/2) of Hippo tumor suppressor pathway preventing their activation and induction of programmed cell death in breast cancer cells. Cell death program can be reactivated by blocking FGFR4 function with a specific inhibitor. These findings suggest new options for eradicating cancer cells with excessive FGFR4 expression.

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M Varjosalo & Lehti Group

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