The Lost Dark Zone (IMAGE)

Max Delbrück Center for Molecular Medicine in the Helmholtz Association

The Lost Dark Zone

Caption

This image shows normal germinal center reaction in the spleen of control animals (left): after antigen contact B cells differentiate in germinal center B cells (red) which are surrounded by naive B cells (green). Within the germinal center the 'dark zone' and 'light zone' characterized by antigen-presenting cells (blue) can be clearly separated. // Disturbed germinal center formation upon FOXO1 ablation (right): In FOXO1-deficient mice, the 'dark zone' is lost and antigen-presenting cells (blue) are scattered throughout the germinal center.

Credit

Research Group of Klaus Rajewsky/MDC Berlin

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