Figure (IMAGE)

Kanazawa University

Figure

Caption

Role of ACSL1 in the CoA conjugation of propionic acid-class NSAIDs in liver. ACSL1, which showed the highest expression among ACS isoforms in human liver, selectively catalyzes propionic acid-class NSAIDs among various kinds of NSAIDs. Because the CoA conjugates with propionic acid-class NSAIDs had the ability of covalent binding to cellular proteins, they would be one of the causal factors inducing NSAIDs-induced toxicity.

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Kanazawa University

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