Bryce Carey and Lydia Finley, The Rockefeller University (IMAGE)

Rockefeller University

Bryce Carey and Lydia Finley, The Rockefeller University

Caption

When study authors Bryce Carey (left) and Lydia Finley (right) exposed mouse embryonic stem cells to an important metabolite, those cells became more likely to renew themselves, appearing as pink colonies on the screen. That metabolite, alpha-ketoglutarate, is also known to be involved in regulating so-called epigenetic marks that control the expression of genes. This is one of the first demonstrations that a metabolite can influence the fate of stem cells.

Credit

Zach Veilleux / The Rockefeller University

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