Krebs Cycle, CNIO (IMAGE)

Centro Nacional de Investigaciones Oncológicas (CNIO)

Krebs Cycle, CNIO

Caption

Mutations in several Krebs cycle genes (IDH1/2, SDH, FH and now MDH2) lead to the accumulation of metabolites (2-HG, SUC and FUM), which cause important changes in gene expression (grey circle).

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CNIO

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