Novel genomic tools increase the accuracy of breast cancer risk assessment (IMAGE)

University of Helsinki

Novel genomic tools increase the accuracy of breast cancer risk assessment

Caption

Clinical gene panel tests identify moderate-risk mutations (including mutations in the CHEK2 gene), and high-risk mutations (including mutations in genes PALB2, BRCA1, and BRCA2). However, moderate to high polygenic risk is a far more common risk factor for breast cancer, but results in a breast cancer risk at least comparable to moderate-risk mutations, and in many cases the risk is even higher. The image illustrates the prevalence of these genetic risk factors per 100 women who have developed breast cancer.

Credit

Nina Mars, University of Helsinki

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