How Obesity Helps Breast Cancer Overcome Anti-Vascular Therapy (1 of 1) (IMAGE)

American Association for the Advancement of Science (AAAS)

How Obesity Helps Breast Cancer Overcome Anti-Vascular Therapy (1 of 1)

Caption

Tissue sections of mouse breast cancer cell tumors before and after anti-VEGF therapy. Right: Adipocyte-rich regions of tumors from animals treated with anti-VEGF. The adipocyte-rich tumor microenvironment in obese mice associates with sustained tumor progression, despite antiVEGF therapy. This material relates to a paper that appeared in the March 14, 2018, issue of Science Translational Medicine, published by AAAS. The paper, by J. Incio at Massachusetts General Hospital in Boston, MA, and colleagues was titled, "Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2."

Credit

J. Incio<i> et al., Science Translational Medicine </i>(2018)

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