Shorter Telomeres Impair Heart Regeneration (IMAGE)

Rockefeller University Press

Shorter Telomeres Impair Heart Regeneration

Caption

Telomerase-deficient mice undergo premature telomere shortening, and so, unlike wild-type mice, they are unable to regenerate damaged heart tissue even at one day old. 28 days after injury, telomerase-deficient heart tissue (right) has larger fibrotic regions (blue) compared with wild-type myocardium (left).

Credit

Aix <i>et al</i>., 2016

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