New Drug Strategy: Target the Ribosome to Halt Protein Production (IMAGE)

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New Drug Strategy: Target the Ribosome to Halt Protein Production

Caption

A cross-section of a stalled ribosome (yellow, gray), showing a newly synthesised protein chain (green) passing through the exit tunnel (boxed). The chemical studied in this paper appears to bind to specific amino acid sequences of the growing protein within that tunnel in the ribosome and make them kink enough to stop progress down the tunnel, halting protein synthesis.

Credit

Bhushan S, Hoffmann T, Seidelt B, Frauenfeld J, Mielke T, Berninghausen O, et al. (2011) doi:10.1371/journal.pbio.1000581

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