Cell Movements (B16-F0, left) and Metastatic (B16-F10, right) Melanoma Cells in the Skin of a Mouse (VIDEO)
Caption
Video 1(top): The "predatory" movements of a metastatic breast cancer cell. Lévy walk visually corresponds to distinct small steps combined with a few long strides, and is also used by animals looking for food.
Video 2(bottom): Cell movements of non-metastatic (B16-F0, left) and metastatic (B16-F10, right) melanoma cells in the skin of a mouse. At the tumor margin (zone 1), where cells are crowded and frequent cell-cell collisions occur, the movements of both types of cells are diffusive. The differences emerge in zones 3 and 4, where metastatic cells move with short and long steps (similar to Lévy walk), while non-metastatic cells' motions are characterized by small steps only (diffusive pattern). The upper part shows the cells (cell nuclei are shown green, blood vessels are red and collagen fibers are blue) moving away from the tumor, and the bottom part represents the tracking of individual cells.
Credit
Reproduced from <em>Nature Communications</em>
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