Machine learning how to make better AAV capsids for gene therapy (IMAGE)

Wyss Institute for Biologically Inspired Engineering at Harvard

Machine learning how to make better AAV capsids for gene therapy

Caption

In their machine learning-based capsid diversification strategy, the team focused on a 28 amino acid peptide within a segment of the AAV2 VP3 capsid protein that exposes the AAV capsid to neutralizing antibodies produced by individuals and thus can be the cause of an immune response against the virus. More purple colored portions of this peptide are buried deeper in the capsid, while yellow parts are exposed on the virus' surface.

Credit

Wyss Institute at Harvard University (original by Drew Bryant)

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