Ewing Cells Respond to CDK12 and PARP Inhibition (IMAGE)

Boston Children's Hospital

Ewing Cells Respond to CDK12 and PARP Inhibition

Caption

Fluorescent staining shows how PARP and CDK12 inhibitors combine to deal a lethal blow to Ewing sarcoma. In the top row, green represents locations of DNA damage incurred by Ewing sarcoma cells. In the bottom row, red represents DNA repair activity. Together, PARP and CDK12 inhibitors lead to Ewing sarcoma cell death.

Credit

Dana-Farber/Boston Children's Cancer and Blood Disorders Center

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