SARS-CoV-2 docks onto the receptor-ACE2 on the surface of lung cells (IMAGE)

Heinrich-Heine University Duesseldorf

SARS-CoV-2 docks onto the receptor-ACE2 on the surface of lung cells

Caption

The coronavirus SARS-CoV-2 docks with its spike protein onto the receptor-ACE2 found on the surface of lung cells. The levels of co-expressed genes with the human receptor-ACE2 were calculated from several publicly available datasets pertaining to lung epithelial cells infected with SARS-CoV-2. The resulting gene-signature consisted of members from the Trans-Membrane-Serine-Protease (TMPRSS) gene family which prime the virus spike protein for cell entry. Other genes from the gene-signature are associated with reduced immune responses and activated inflammation, Reactive Oxygen Species (ROS) and cellular stress.

Credit

WruckW /AdjayeJ, HHU Duesseldorf, Germany

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