TB cAMP Receptor Protein (Off State) (IMAGE)

National Institute of Standards and Technology (NIST)

TB cAMP Receptor Protein (Off State)

Caption

Computer model of the defined structure for the "off" state of the cyclic AMP receptor protein (CRP) found in Mycobacterium tuberculosis. The two subunits of the protein (colored purple on the left and green on the right) are genetically identical but, surprisingly were found to be asymmetric (different in shape) for the areas shown in white (top). This is the state of the CRP that is unable to activate genes necessary for the microbe's survival.

Credit

Travis Gallagher, NIST

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