Even skin shielded from the sun accumulates genomic DNA changes from UV light (IMAGE)

PLOS

Even skin shielded from the sun accumulates genomic DNA changes from UV light

Caption

Fig 1. Schematics of the study design. From each donor, we obtained blood for whole-genome sequencing. In addition, we obtained skin biopsies from the hips of the donors from which fibroblasts and melanocyte clonal lineages were obtained. Fibroblasts were grown up to a million cells and their DNA was directly used for whole-genome sequencing, while melanocytes grew up to 10,000 cells and the DNA was whole-genome amplified and thereafter sequenced.

Credit

Saini N et al., 2021, PLOS Genetics

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