Identification of DNA repair proteins by mass spectrometry (IMAGE)

Max Planck Institute of Biochemistry

Identification of DNA repair proteins by mass spectrometry

Caption

Collision of the DNA replication machinery with lesions in the DNA triggers the recruitment of a large number of DNA repair factors (yellow) that help to repair the lesions. In proteomic analyses proteins are fragmented and identified by their mass and charge. Proteomic profiles (right) indicate the maximal accumulation of DNA replication and repair factors on the DNA.

Credit

Markus Raeschle / Copyright: MPI of Biochemistry

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