Aurora B in Action (IMAGE)

Rockefeller University Press

Aurora B in Action

Caption

Although XIST initiates the silencing of the chromosome, the RNA (green) is temporarily released during mitosis (left). By manipulating XIST binding in vivo, Hall et al. discover that Aurora B kinase regulates the RNA’s association with chromatin: XIST is retained on the X chromosome in mitotic cells lacking Aurora B (right).

Credit

Hall, L.L., et al. 2009. J. Cell Biol. doi:10.1083/jcb.200811143

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