Histology and <i>in vitro</i> Model (IMAGE)

Heinrich-Heine University Duesseldorf

Histology and <i>in vitro</i> Model

Caption

Histological section of a liver biopsy of a healthy individual (upper left) and an NAFLD patient (upper right) (1). Lipid droplets are visible as vacuoles. Induced pluripotent stem cells, which express the pluripotency marker OCT4 (middle left, green), are in vitro differentiated into hepatocyte-like cells, characterized by the expression of ALBUMIN (ALB, middle right, red) and alpha-fetoprotein (AFP, middle green right). Unstimulated in vitro derived hepatocyte-like cells do not incorporate lipid droplets (lower left) while they develop massive lipid droplets after stimulation with oleic acid (lower right, green).

Credit

Graffmann N et al.

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