novel urea transporters (UT) inhibitor with a diarylamide scaffold (IMAGE)
Caption
In the present study, a novel urea transporters (UT) inhibitor with a diarylamide scaffold was discovered by high throughput screening. Optimization of the hit compound E04 led to the identification of 1H, with orally diuretic activity, more powerful inhibition activity on UT-A1, favorable pharmacokinetic characteristics and without electrolyte disturbance.
Credit
Acta Pharmaceutica Sinica B
Usage Restrictions
None
License
Licensed content