Breast Cancer Drug, Olaparib, Depletes Store of Immature Eggs in Mouse Ovaries (IMAGE)

European Society of Human Reproduction and Embryology

Breast Cancer Drug, Olaparib, Depletes Store of Immature Eggs in Mouse Ovaries

Caption

In normal mouse primordial eggs (stained green), we never detect DNA damage. But, on top of killing primordial eggs, olaparib causes DNA damage in some eggs that survive, suggesting they will either soon die, or be too poor quality to give rise to a healthy baby.

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Human Reproduction

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