Figure 8 (IMAGE)

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Figure 8

Caption

MLN4924 treatment induces DNA damage by stabilizing CDT1 and accumulates the cells in S phase which are enhanced by MLN4924/cisplatin co-treatment. (A) Representative images of Ki-67 staining (40&times; magnification) and quantitation of Ki-67 IHC. The results were from 4 tumors and data were presented as mean ± SD. **p < 0.001 indicates a significant difference. (B) WB showing the levels of cleaved PARP, CDT1, &gamma;H2AX and p21 in vehicle, MLN4924, Cisplatin, and MLN4924/Cisplatin treated tumors. (C) A model showing the pathway leading to apoptosis and senescence upon NAE1 inhibition by MLN4924 and synthetic lethality upon MLN4924/cisplatin cotreatment.

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Correspondence to - Alo Ray - Alo.Ray@osumc.edu

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