Figure 4 (IMAGE)

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Figure 4

Caption

Apoptosis assay of NRXN1-targeted ADC at IC50 dose calculated by growth inhibition curves. Late apoptotic cells were quantified by Cy7-conjugated annexin-V and PI using flow cytometry. Results were analyzed using a one-way ANOVA followed by the Dunnett multiple comparisons test (*P < 0.05; **P < 0.01; ***P < 0.0001 versus no-treatment control group; Dunnett test). Error bars represent the SD of the mean. mAb, monoclonal antibody.

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Correspondence to - Daiya Takai - dtakai-ind@umin.ac.jps and Takuma Yotsumoto - tyotsumoto-ths@umin.ac.jp

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