Figure 5 (IMAGE)

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Figure 5

Caption

in vivo and ex-vivo growth kinetics of B6CaP. Growth rates of CR sublines in castrate hosts, measured as time from injection to 1.5 cm tumor size, was significantly slower than parental B6CaP cells in intact hosts (A, 42.9 vs 63.3 days, p < 0.001). Organoids retained androgen sensitivity in vitro, growing rapidly to form organoids/spheres in media containing DHT, but rarely forming small spheres without DHT (B). Three weeks after plating 105 cells as organoids, cells in media containing DHT had expanded 10-fold, but total cell number had decreased in media without DHT (C).

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Correspondence to - Edward M. Schaeffer - e-schaeffer@northwestern.edu

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