Figure 1 (IMAGE)

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Figure 1

Caption

Domain architecture of p53 and nomenclature of clones generated via CRISPR-Cas9. (A) Highlights the domain architecture of p53 with emphasis on the sgRNA designed to target the oligomerization (OD) and C-terminal domain (CTD) of mtp53. (B) CRISPR-Cas9 was used to generate clones with either OD or CTD mutations. Clones were selected with FACS sorting of eGFP positive cells. Selected clones were named based on the region and type of mutation that resulted.

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Correspondence to - Jill Bargonetti - bargonetti@genectr.hunter.cuny.edu

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Copyright: © 2021 Ellison et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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