Figure 4 (IMAGE) Impact Journals LLC Caption Gene set enrichment plot of the EGFR and PI3K-AKT-mTOR signaling pathways for the copanlisib and cetuximab cohorts. (A) Cetuximab-responsive cohort (labeled as "REST' on the plot) presented with a differentially stronger activity of EGFR signaling (MSigDB id M563) compared to the cetuximab-resistant HNSCC samples (p = 0.040; false discovery rate, q = 0.022). (B) Copanlisib-responsive cohort (labeled as "Intermediate' on the plot) was found to harbor a differentially stronger activity of PI3K-AKT-mTOR pathway (MSigDB id M5923) compared to the copanlisib-resistant HNSCC samples (p = 0.03; q = 0.067). Credit Correspondence to - Konrad Klinghammer - konrad.klinghammer@charite.de Usage Restrictions Copyright: © 2020 Klinghammer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.