Figure 4 (IMAGE)
Caption
Activity of Neo™-L19 in F9 teratocarcinoma or WEHI-164 fibrosarcoma tumor bearing mice. (A) F9 teratocarcinoma. Left: Tumor bearing mice received 3 injections (?) of Neo™-L19, Neo™-KSF or saline (PBS) when the tumors reached an average size of 90 mm3. The data is represented as the mean ± SD. Statistical analysis was performed by two-way ANOVA with post Bonferroni test (Not significant P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). All the immunocytokine treatments were statistically different from the saline treatment on day 14 (****P < 0.0001). On day 20, Neo™-L19 10 μg per inj (**P < 0.01) and Neo™-L19 100 μg per inj (****P < 0.0001) were different from the Neo™-KSF (100 μg per inj) group. Right: Body weight changes during the treatment represented as the mean ± SD. (B) WEHI-164 fibrosarcoma. Left: Tumor bearing mice received 2 equimolar injections (?) of Neo™-L19, Neo™-KSF, His6-Neo™ or saline (PBS) when the tumors reached an average size of 90 mm3. The data is represented as the mean ± SD. On day 16, the Neo™-L19 (****P < 0.0001) and Neo™-KSF (*P < 0.05) groups showed a significant difference to the saline group. On day 16, Neo™-L19 was different from the His6-Neo™ (***P < 0.001) and Neo™-KSF (*P < 0.05) groups. On day 17, Neo™-L19 and Neo™-KSF was not significantly different (P > 0.05). Right: Body weight changes during the treatment represented as the mean ± SD. Only significant differences between treatment groups have been indicated. ¥only two mice remaining in the group. CR: complete response.
Credit
Correspondence to - Michael R. Mortensen - michael.mortensen@pharma.ethz.ch
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Copyright: © 2020 Mortensen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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